The Chobe Game Reserve was officially created in 1960, though smaller than initially desired. In 1967, the reserve was declared a national park. At that time there were several industrial settlements in the region, especially at Serondela, where the timber industry proliferated. These settlements were gradually moved out of the park, and it was not until 1975 that the whole protected area was exempt from human activity. Nowadays traces of the prior timber industry are still visible at Serondela along the river front in the park.
The Chobe River, which flows along the Northeast border of the park, is a major watering spot, especially in the dry season (May through October) for large breeding herds of elephants, as well as families of giraffe, sable and cape buffalo. The flood plains are the only place in Botswana where the puku antelope can be seen.